Description
MOTS-c 40mg from Evolve Peptides is 40mg of MOTS-c in a sealed glass vial. MOTS-c is a mitochondrial-derived peptide. It’s for in-vitro and lab research only.
About MOTS-c
MOTS-c is a 16-amino-acid peptide encoded in the mitochondrial 12S rRNA gene. It was described in 2015 by Pinchas Cohen’s group at USC.
It acts on metabolism, in part through AMPK.
How MOTS-c works
Most proteins are coded in the cell nucleus. MOTS-c is one of a handful of peptides coded in mitochondrial DNA instead. Its main target looks like the folate cycle, which feeds into AMPK activation and better glucose handling in muscle.
Under stress it can move into the nucleus and change gene expression. Circulating levels drop with age in both mice and people, which is why it’s studied in metabolism and aging.
MOTS-c 40mg specifications
- Compound: MOTS-c
- CAS number: 1627580-64-6
- Molecular formula: C101H152N28O22S2
- Molar mass: 2,174.6 g/mol
- Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
- Amount: 40mg per vial
- Form: lyophilized (freeze-dried) powder
- SKU: EVP-MOTSC-40
- Use: laboratory research only
Published MOTS-c studies
Lee and colleagues reported in Cell Metabolism (2015) that MOTS-c prevented diet-induced obesity and insulin resistance in mice.
Reynolds and colleagues showed in 2021 that it improved physical capacity in young, middle-aged and old mice.
For the original studies, try this PubMed search.
MOTS-c 40mg lab reports and purity
Scroll through the MOTS-c 40mg photos and you’ll find:
- A certificate of analysis with identity, measured quantity and HPLC purity.
- An endotoxin report from a kinetic LAL assay.
Click any image to zoom in on the numbers. Some of these reports were run on a different vial size of MOTS-c from the same production. The purity figure carries over; the quantity line refers to the vial that was tested.
MOTS-c 40mg reconstitution and concentration
Concentration is just the amount in the vial divided by the water you add. With 40mg in this vial:
- 2ml of bacteriostatic water gives 20mg/ml
- 3ml of bacteriostatic water gives 13.33mg/ml
- 5ml of bacteriostatic water gives 8mg/ml
Pick the volume that keeps your own calculations simple, then write the concentration and the mixing date on the label.
Use sterile bacteriostatic water. Warm the sealed vial to room temperature first so no condensation gets in, add the water slowly along the glass wall, and swirl gently until it’s clear. Never shake.
Storage and shelf life
Unopened, keep MOTS-c 40mg in a fridge at 2 to 8°C, or in a freezer at -20°C if it’ll be a while before you use it. Keep it out of direct light. Once mixed, keep it refrigerated and use it within about 28 days, which is how long bacteriostatic water stays good after opening.
Other MOTS-c sizes
- MOTS-c 10mg: 10mg for $60.00, about $6.00 per mg
- MOTS-c 40mg (this page): 40mg for $179.90, about $4.50 per mg
MOTS-c 40mg is the largest size we stock and the cheapest per milligram. It suits longer studies where you’d otherwise reorder.
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Browse the full anti-aging peptides and weight loss peptides range, or see every vial on our research peptides page.
MOTS-c 40mg questions
How much is in the MOTS-c 40mg vial?
40mg of lyophilized powder. The amount is printed on the label.
Which size should I buy?
Pick by how much you’ll use. Bigger vials cost less per milligram, smaller ones mean less sits open in the fridge. The size comparison above lists every MOTS-c option.
What do I mix MOTS-c 40mg with?
Sterile bacteriostatic water. The reconstitution section above shows the concentration for each volume.
How should I store it?
Sealed vials go in the fridge, or the freezer for long-term storage. Once mixed, refrigerate and use within about 28 days.
Can MOTS-c be used in people or animals?
No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.
Buy MOTS-c 40mg online
MOTS-c 40mg is in stock at $179.90. Choose your quantity, add it to the cart and check out in a couple of minutes. Add a vial of bacteriostatic water if you don’t have any, so you’re ready to reconstitute when it arrives.
Need more for the same project? See the rest of our anti-aging peptides and weight loss peptides.
For laboratory research use only. Not for human or veterinary use. Not evaluated by the FDA.
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