Description
FOXO4-DRI 10mg from Evolve Peptides is 10mg of FOXO4-DRI in a sealed glass vial. FOXO4-DRI is a D-retro-inverso peptide. It’s for in-vitro and lab research only.
FOXO4-DRI at a glance
FOXO4-DRI is a modified peptide that blocks the interaction between FOXO4 and p53. It’s built from D-amino acids in reverse order, which makes it resistant to enzymes.
It’s studied as a senolytic, meaning a compound that clears senescent cells.
FOXO4-DRI mechanism of action
Senescent cells have stopped dividing but don’t die. In them, the FOXO4 protein holds p53 in the nucleus, which keeps p53 from triggering cell death.
FOXO4-DRI is a decoy that competes with FOXO4 for p53. With p53 released, it moves to the mitochondria and the senescent cell dies. Healthy cells barely use the FOXO4-p53 link, so they’re largely spared in the mouse studies.
FOXO4-DRI 10mg specifications
- Compound: FOXO4-DRI
- CAS number: 2460055-10-9
- Sequence: D-retro-inverso peptide
- Amount: 10mg per vial
- Form: lyophilized (freeze-dried) powder
- SKU: EVP-FOXO4-10
- Use: laboratory research only
What the research says about FOXO4-DRI
Baar and colleagues reported in Cell (2017) that FOXO4-DRI pushed senescent cells into apoptosis and restored fur density, fitness and kidney function in aged and fast-aging mice.
A 2020 study tested it on senescent Leydig cells in aged mice.
The primary literature is on PubMed. Here’s a search for FOXO4-DRI studies to start from.
FOXO4-DRI purity and lab testing
The product photos for FOXO4-DRI 10mg include:
- A certificate of analysis with identity, measured quantity and HPLC purity.
- An endotoxin report from a kinetic LAL assay.
Click any image to zoom in on the numbers. Where a report names a different size, the lab tested a sibling FOXO4-DRI vial. Read the purity line, not the quantity line, when comparing.
FOXO4-DRI 10mg reconstitution and concentration
Here’s the math for 10mg of peptide:
- 1ml of bacteriostatic water gives 10mg/ml
- 2ml of bacteriostatic water gives 5mg/ml
- 3ml of bacteriostatic water gives 3.33mg/ml
Go with whichever number is easiest to work with in your protocol, and label the vial with the concentration and the date you mixed it.
Bacteriostatic water is the standard choice. Add it slowly so it runs down the side of the vial, then swirl or roll until everything dissolves. Shaking can damage the peptide, so skip it.
Storage and shelf life
Unopened, keep FOXO4-DRI 10mg in a fridge at 2 to 8°C, or in a freezer at -20°C if it’ll be a while before you use it. Keep it out of direct light. Once mixed, keep it refrigerated and use it within about 28 days, which is how long bacteriostatic water stays good after opening.
Other FOXO4-DRI sizes
- FOXO4-DRI 5mg: 5mg for $159.90, about $31.98 per mg
- FOXO4-DRI 10mg (this page): 10mg for $269.90, about $26.99 per mg
For longer projects FOXO4-DRI 10mg works out cheapest per milligram, and you’ll reorder less often.
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Browse the full anti-aging peptides range, or see every vial on our research peptides page.
FOXO4-DRI 10mg FAQ
How much is in the FOXO4-DRI 10mg vial?
10mg of lyophilized powder. The amount is printed on the label.
How should I store it?
Sealed vials go in the fridge, or the freezer for long-term storage. Once mixed, refrigerate and use within about 28 days.
Can FOXO4-DRI be used in people or animals?
No. It’s sold for laboratory research only and isn’t approved for human or veterinary use.
Is it in stock?
Yes, FOXO4-DRI 10mg is in stock now.
Is FOXO4-DRI 10mg lab tested?
Yes. The lab reports are in the product photos, so you can check purity before you order.
Buy FOXO4-DRI 10mg from Evolve Peptides
Order FOXO4-DRI 10mg now for $269.90. It’s in stock, and checkout takes about two minutes. Add a vial of bacteriostatic water if you don’t have any, so you’re ready to reconstitute when it arrives.
Need more for the same project? See the rest of our anti-aging peptides.
For laboratory research use only. Not for human or veterinary use. Not evaluated by the FDA.
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