Description
Our FOXO4-DRI 5mg vial holds 5mg of lyophilized FOXO4-DRI, a D-retro-inverso peptide. It’s intended for lab research only.
FOXO4-DRI at a glance
FOXO4-DRI is a modified peptide that blocks the interaction between FOXO4 and p53. It’s built from D-amino acids in reverse order, which makes it resistant to enzymes.
It’s studied as a senolytic, meaning a compound that clears senescent cells.
How FOXO4-DRI acts in the lab
Senescent cells have stopped dividing but don’t die. In them, the FOXO4 protein holds p53 in the nucleus, which keeps p53 from triggering cell death.
FOXO4-DRI is a decoy that competes with FOXO4 for p53. With p53 released, it moves to the mitochondria and the senescent cell dies. Healthy cells barely use the FOXO4-p53 link, so they’re largely spared in the mouse studies.
FOXO4-DRI 5mg technical data
- Compound: FOXO4-DRI
- CAS number: 2460055-10-9
- Sequence: D-retro-inverso peptide
- Amount: 5mg per vial
- Form: lyophilized (freeze-dried) powder
- SKU: EVP-FOXO4-5
- Use: laboratory research only
Published FOXO4-DRI studies
Baar and colleagues reported in Cell (2017) that FOXO4-DRI pushed senescent cells into apoptosis and restored fur density, fitness and kidney function in aged and fast-aging mice.
A 2020 study tested it on senescent Leydig cells in aged mice.
The primary literature is on PubMed. Here’s a search for FOXO4-DRI studies to start from.
Reconstituting FOXO4-DRI 5mg
The volume of water you add sets the concentration. For a vial holding 5mg:
- 1ml of bacteriostatic water gives 5mg/ml
- 2ml of bacteriostatic water gives 2.5mg/ml
- 3ml of bacteriostatic water gives 1.67mg/ml
Pick the volume that keeps your own calculations simple, then write the concentration and the mixing date on the label.
Bacteriostatic water is the standard choice. Add it slowly so it runs down the side of the vial, then swirl or roll until everything dissolves. Shaking can damage the peptide, so skip it.
Storing FOXO4-DRI 5mg
The dry powder keeps best cold: 2 to 8°C in the fridge, or -20°C for long-term storage. After reconstitution, store it in the fridge and finish it within roughly four weeks.
FOXO4-DRI 5mg lab reports and purity
This listing doesn’t have a lab report in its photos yet. The FOXO4-DRI 10mg listing shows reports for FOXO4-DRI from our recent testing.
Other FOXO4-DRI sizes
- FOXO4-DRI 5mg (this page): 5mg for $159.90, about $31.98 per mg
- FOXO4-DRI 10mg: 10mg for $269.90, about $26.99 per mg
FOXO4-DRI 5mg is the entry size, handy when you only need a little or want to try FOXO4-DRI before committing to a bigger vial.
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Browse the full anti-aging peptides range, or see every vial on our research peptides page.
FOXO4-DRI 5mg questions
How much is in the FOXO4-DRI 5mg vial?
5mg of lyophilized powder. The amount is printed on the label.
Is FOXO4-DRI 5mg lab tested?
Yes. We test FOXO4-DRI by production run, and the batch number on the label is what the paperwork is filed under.
Which size should I buy?
Pick by how much you’ll use. Bigger vials cost less per milligram, smaller ones mean less sits open in the fridge. The size comparison above lists every FOXO4-DRI option.
What do I mix FOXO4-DRI 5mg with?
Sterile bacteriostatic water. The reconstitution section above shows the concentration for each volume.
How should I store it?
Sealed vials go in the fridge, or the freezer for long-term storage. Once mixed, refrigerate and use within about 28 days.
Buy FOXO4-DRI 5mg online
Order FOXO4-DRI 5mg now for $159.90. It’s in stock, and checkout takes about two minutes. Add a vial of bacteriostatic water if you don’t have any, so you’re ready to reconstitute when it arrives.
Need more for the same project? See the rest of our anti-aging peptides.
For laboratory research use only. Not for human or veterinary use. Not evaluated by the FDA.
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